Evidence of increased odds of essential tremor in Parkinson's disease
Identifieur interne : 002855 ( Main/Exploration ); précédent : 002854; suivant : 002856Evidence of increased odds of essential tremor in Parkinson's disease
Auteurs : Eng-King Tan [Singapour] ; Seng-Swim Lee [Singapour] ; Fook-Chong S. [Singapour] ; Sau-Ying Lum [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Dopamine Agonists (therapeutic use), Dose-Response Relationship, Drug, Drug Administration Schedule, Essential Tremor (complications), Essential Tremor (diagnosis), Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Severity of Illness Index, Tremor, association, essential tremor.
- MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- complications : Essential Tremor, Parkinson Disease.
- diagnosis : Essential Tremor.
- drug therapy : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22005
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-05-15">2008-05-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="993">993</biblScope><biblScope unit="page" to="997">997</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E3AB0989344EB1E6B45B7AADB4BE0A4EF90A5556</idno><idno type="DOI">10.1002/mds.22005</idno><idno type="ArticleID">MDS22005</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Dopamine Agonists (therapeutic use)</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Essential Tremor (complications)</term><term>Essential Tremor (diagnosis)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Severity of Illness Index</term><term>Tremor</term><term>association</term><term>essential tremor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Dose-Response Relationship, Drug</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Tremblement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">In a case control study using a standardized protocol, 600 subjects were evaluated for essential tremor (ET). We demonstrated that ET was significantly more frequent in patients with Parkinson's disease (PD) (12/204, 5.9%) compared to diseased controls (2/206, 1%) and healthy controls (1/190, 0.5%). A regression analysis with ET as outcome and group (either PD or healthy controls or diseased controls) as independent variable (adjusting for age and sex) revealed that PD had higher odds of having ET than diseased controls (OR = 5.43, 95% CI = 1.16, 25.39, P < 0.001) and healthy controls (OR = 10.87, 95% CI = 1.39, 85.15, P < 0.001). The low frequency of ET in our controls was further confirmed in a follow‐up study in a group of age and gender matched general medical patients who attended an outpatient clinic (0% frequency). Eight of 204 PD (3.9%) compared to none of diseased (0%) (P = 0.004) and healthy controls (0%) (P = 0.008) had a prior diagnosis of ET. The duration of ET symptoms in patients with PD was 25.1 ± 19.6 (range 3–60) years. A multivariate analysis demonstrated that a lower dose of levodopa (OR = 0.993, 95%CI for OR = 0.988, 0.997, P < 0.001) and a higher age of onset of disease (OR = 1.108, 95%CI for OR = 1.035, 1.187, P < 0.001) were associated with increased odds of PD with ET, compared to patients with PD without ET. In our Asian population, patients with PD were 5 to 10 times more likely to have ET compared to diseased and healthy controls, suggesting that the association of ET and PD is unlikely to be ethnicity‐specific. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></noRegion><name sortKey="Lee, Seng Wim" sort="Lee, Seng Wim" uniqKey="Lee S" first="Seng-Swim" last="Lee">Seng-Swim Lee</name><name sortKey="Lum, Sau Ing" sort="Lum, Sau Ing" uniqKey="Lum S" first="Sau-Ying" last="Lum">Sau-Ying Lum</name><name sortKey="S, Fook Hong" sort="S, Fook Hong" uniqKey="S F" first="Fook-Chong" last="S.">Fook-Chong S.</name><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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